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coadministration may cause serotonin syndrome do not use concomitantly or initiate bupropion within 14 days of stopping an maoi conversely, at least 14 days should be allowed after stopping bupropion before starting an maoi antidepressant starting bupropion in a patient who is being treated with linezolid or iv methylene blue is contraindicated because of an increased risk of serotonin syndrome if linezolid or iv methylene blue must be administered, discontinue bupropion immediately and monitor for cns toxicity; may resume 24 hr after last linezolid or methylene blue dose or after 2 weeks of monitoring, whichever comes first.
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